Experts in: Proteomics
Professor Chaurand and his group are developing methodologies for analyzing the molecular content of thin tissue sections by mass spectrometry in a region-specific manner. A systematic analysis makes it possible to reconstruct molecular images (proteins, peptides, lipids, metabolites, etc.) that can be directly correlated to the histologies present within the sections and the health of biopsies.
Professeur titulaire, Professeur accrédité
- Bioanalytical chemistry
- Mass spectrometry
- Protein modifications
- Cell signalling
- Analytical chemistry
Our research program focuses on the development and application of proteomics and bioanalytical mass spectrometry to the identification of trace-level proteins in complex cell extracts. Our research efforts bring a multidisciplinary team approach using methods and techniques from bioanalytical chemistry, protein chemistry, biochemistry and cellbiology.More specifically, our research interests span from the development of cell fractionation methods and protein enrichment techniques for phospho- and glycoproteins to the coupling of multidimensional capillary liquid chromatography to mass spectrometry and its application to the identification of post-translational modifications (sites and stoechiometry). We are also developing chemometric and bioinformatics tools for data mining of peptides in complex protein digests. These different tools are used in proteomics research programs to gain further insights to complex cell biology paradigms such as organelle biogenesis (phagosome and endosome), cell signalling in cancer, and the identification of peptides presented by the major histocompatibility complexproteins.