Titre : Three-Dimensional DNA Structures for Biological and Materials Applications.
La conférence sera prononcée par la professeure Hanadi Sleiman du Département de chimie de l'Université McGill. Elle sera donnée en anglais.
Résumé : Three-dimensional structures made of DNA hold the potential to encapsulate and release drugs, regulate the assembly and activity of proteins,and organize networks for catalysis and biomolecule crystallization. This talk will describe our research group’s synthetic approaches to 3D-DNA structures, such as DNA cages and nanotubes. These can be accessed with deliberate variation of geometry, size, single- and double-stranded forms, permeability and length. They can be dynamically switched to different internal volumes, and can be ‘opened’ or closed with specific DNA strands. The size-selective encapsulation of nanoparticles and small molecules within these host structures, and the release of this cargo when specific DNA strands are added will be shown. We will also describe the use of these cages for the anisotropic organization of transition metals and hydrophobic units, thus defining new modes of protein-inspired interactions. These compact 3D-DNA structures can travel across the plasma membrane of a number of mammalian cells and result in efficient gene silencing. The molecules shown here represent a new class of selective cellular probes and drug delivery tools, and can assist the development of nucleic acid therapeutic routes.
Références sélectionnées : Science, 2008, 321, 1795; Nature Chem. 2013, 5, 868; J. Am. Chem. Soc. 2013, 135, 11283; ACS Nano 2013, 7, 3022; Chem. Sci. 2012, 3, 1980; J. Am. Chem. Soc. 2012, 134 14382; J. Am. Chem. Soc. 2012, 134, 4280; J. Am. Chem. Soc. 2012, 134, 2888; J. Am. Chem. Soc. 2010, 132, 10212; Nature Chem. 2010, 2, 319; Nature Chem. 2009, 1, 390; Nature Nanotech. 2009, 4, 349; J. Am. Chem. Soc. 2007, 129, 13376.