Titre : Development of Bile Acid-Based Nanoparticles for Biomedical Applications.
Endroit : Pavillon Roger-Gaudry, salle G-615 à 11 h 30.

Cette conférence sera prononcée (en anglais) par Monsieur Alexander Cunningham, étudiant au doctorat, du laboratoire de Julian Zhu, professeur au Département de chimie de l'Université de Montréal.

Résumé : Over 40% of recently discovered therapeutic molecules are insoluble in physiological conditions rendering them either ineffective or toxic. The use of drug delivery nanocarriers enables the safe and efficient spatiotemporal delivery of therapeutic molecules. Despite the breadth of research on the topic, very few successful polymer-based drug delivery systems are currently on the market due to insufficient biocompatibility, inefficient drug encapsulation, or unstable formulations. Bile acid-based amphiphilic block copolymers offer a promising solution. Bile acids are excellent candidates as starting materials in the design of biomaterials due to their non-toxicity, amphiphilic properties, relative abundance in nature, and convenience of chemical modifications. Specifically, using cholic acid as an initiator, poly(ethylene glycol) and poly(allyl glycidyl ether) of various chain lengths were synthesized via anionic ring-opening polymerization to help in the flexibility and stability of the micelles for combined drug and gene delivery directed towards anti-cancer treatment.

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