Titre : Merging Nanotechnology and Luminescence Signalling: Dye-Doped Silica Nanoparticles for Biomedical Applications.
Endroit : Pavillon J.-A.-Bombardier, salle 1035 de 10 h à 11 h.
Hôte : Professeur William Skene.

La conférence sera prononcée (en anglais) par la professeure Nelsi Zaccheroni, du Département de chimie de l'University of Bologna (Italie).

Résumé : Among the numerous possibilities of functional nanostructures, we focused on new dye-doped silica nanoparticles and we investigated different synthetic approaches to obtain mono-disperse, water soluble nanoparticles (NPs) with a silica core (10 nm diameter) and an organic shell (7 nm thick) that can host a certain number of dyes of different nature. The optimization and proper design of these materials allowed us to move from the study of molecular luminescent labels to nanostructured species presenting improved properties. The fluorophores can be irreversibly included into the nanoparticles to obtain very bright and photostable nanoobjects with tunable emission spectral profiles and excitation wavelengths. Moreover, their chemical versatility allows them to be coupled with suitable biomolecules for specific target recognition. Incorporation of dyes active in the therapeutic and diagnostic transparency window facilitates the excitation and detection of the NPs through biological tissues and, therefore, their implementation for medical applications. Examples of in-vivo, ex-vivo and in-vitro imaging will be presented.

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