Titre : Palladium-Catalyzed Direct Functionalization of Alpha-Cyclopropyl Amino Acid-Derivatives.
Endroit : Pavillon Roger-Gaudry, salle G-1015 11 h.

Cette conférence sera prononcée (en anglais) par Madame Carolyn Ladd, étudiante au doctorat, du laboratoire d'André Charette, professeur au Département de chimie de l'Université de Montréal.

Résumé : In the last ten years, extensive progress has been made in the area of direct C–H functionalization and the synthetic utility of these reactions has been demonstrated. Cyclopropanes represent an underexplored target for direct functionalization, despite their known reputation as widely used motifs in current top-selling market pharmaceutical and agrochemicals. Within this class of compounds, cyclopropyl amino acids are unique substrates that have found interesting applications in peptidomimetics as the cyclopropyl moiety can impart greater rigidity leading to enhanced biological activity. However, accessing cyclopropyl amino acids and their derivatives remains a challenging synthetic problem. This seminar will describe the development of a palladium-catalyzed direct functionalization approach towards accessing cyclopropyl alpha-amino acid derivatives

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