Titre : Plasmonic Nanosystems: New Tools for Early Diagnostics and Therapy.

Cette conférence sera prononcée (en anglais) par le Professeur Tuan Vo-Dinh, du Département d'ingénierie biomédicale de la Duke University.

Résumé : This lecture presents the development and application of nanosensor and nanoprobe technology for early biomedical diagnostics and therapy. This presentation describes several areas of research at the nexus of engineering, biology, medicine and nanotechnology: (1) plasmonics nanoprobes and nanochips using surface-enhanced Raman scattering (SERS) for multiplex detection; (2) nanosensors for in vivo analysis of a single cell for molecular diagnostics; and (3) multi-modality nanoplatforms for cancer theranostics, combining detection and therapy. A new generation of nanosensors and nanoprobes combining bio-recognition and nanotechnology has been developed for in vivo monitoring of biochemical processes in a single living cell. These studies demonstrate the applications of a new type of SERS plasmonics “molecular sentinel” nanoprobes for detection of mRNA/microRNA biomarkers for cancer and infectious diseases. The use of nanobiosensors allows for measurements of apoptotic signaling pathways inside a single cell treated with anticancer drug. Also, new multi-modality nanoprobes provide a unique nanoplatform with capabilities to perform pre-operative tumor scanning with magnetic resonance imaging (MRI) and X-ray computed tomography (CT), intra-operative tumor detection with surface-enhanced Raman scattering (SERS) and two-photon luminescence (TPL) as well as post-operative photothermal therapy (PTT). Such nanoprobes open new horizons to a host of applications in biomedical diagnostics at the point of care, global health, molecular imaging, biology research, ultra-high throughput screening, and investigations of the therapeutic action of pharmaceutical agents.

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