Titre :Synthesis, Cyclizations, and Switches: Controlling Regiochemistry, and Molecular Motion, in π-Extended Heterocycles Endroit : Pavillon J.-Armand Bombardier, salle 1035 à 14 h.Hôte : Professeur James Wuest.

Cette conférence sera prononcée (en anglais) par la professeure Sara Eisler du département de chimie de l'université du Nouveau-Brunswick.

Résumé :We have found that intramolecular, nucleophilic cyclization reactions can be performed under mild conditions to give a variety of p-extended isoindolinone (IIN), pyrrolone, and pyridinone containing products in high yields. Multiple cyclizations can be performed simultaneously within a single molecule, and these extended systems are thermally stable, easily functionalizable, and strongly fluorescent. In addition, controlled switching between isomeric forms of the IINs can be induced when exposed to UV and visible light, thus representing an entirely new family of multi-stable molecular switches. We have used the sequential E-Z isomerizations of photoresponsive IIN moieties to build multi-stable molecular switches with unusual switching motifs. These systems can be reversibly and controllably transformed between several different stable conformations, and will respond to orthogonal stimuli. The synthesis, electronic properties, and switching characteristics of several responsive IIN-containing small molecules will be presented.

Information supplémentaireAnnonce PDF de la conférence