Titre : Exploration of Cooperative Asymmetric Catalysis Toward Efficient Synthesis of Therapeutics.

Cette conférence sera prononcée (en anglais) par Monsieur Naoya Kumagai, Ph.D., chercheur-en-chef du laboratoire de chimie organique de synthèse au sein de l'Institute of Microbial Chemistry à Tokyo, Japon.

Ce dernier sera de passage sur le continent après avoir assisté au 19th International Symposium on Homogeneous Catalysis à Ottawa.

Résumé :
Cooperative catalysis has proven to be a powerful strategy for promoting stereoselective reactions under mild reaction conditions with perfect atom economy. The specific interactions between the catalyst components and substrates are precisely orchestrated to elicit high catalytic efficiency and excellent control of the stereochemical course. Two types of newly designed cooperative asymmetric catalysts have been developed to enable 23 enantioselective reactions, which were applied to streamlined syntheses of therapeutics and biologically active compounds.

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