Titre : New Chelation-Assisted Transformations of C-H Bonds Utilizing a Bidendate Directing Group.

Cette conférence sera prononcée (en anglais) par le Professeur Naoto Chatani du Département de chimie appliquée de la Osaka University (Japon).

Résumé : Chelation-assistance is now one of more reliable methods for transforming C-H bonds. These reactions permit the highly regioselective transformation of C-H bonds proximal to a coordinating functional group into a new C-X bond. A wide variety of functional groups has been evaluated as directing groups to date in the transformation of C-H bonds. However, in spite of the tremendous progress made to date, the development of new types of directing groups continues to be important, in terms of exploring novel types of transformations of C-H bonds that cannot be achieved by conventional directing groups. In 2005, Daugulis reported the arylation of unactivated C(sp³)-H bonds using 8-aminoquinoline and picolinamide as a N,N-bidentate directing group in conjunction with Pd(OAc)₂ as the catalyst. Encouraged by these promising results, a number of transformations of C-H bonds have since been developed using similar chelation systems. Herein, we will present some new transformations of C-H bonds by taking advantage of N,N-bidentate directing groups, such as 2-pyridynylmethylamine and 8-aminoquinoline in the presence of transition metal complexes.

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