Analyses offered by the mass spectrometry laboratory

• Determination of nominal mass - available ionization sources: ESI, APCI

• Accurate mass analysis (m/z 50-8000) - available ionization sources: ESI, APCI, APGC

• Analysis of high molecular weight species (proteins, DNA, RNA)

• Quantification of endogenous or exogenous species by LC-MS/MS

• Purification by preparatory liquid chromatography  (usually 2-200 mg)

• Chiral and achiral separations by SFC-MS and/or SFC-UV

Example of applications

• Cannabinoid (THC, CBD et al.) qualitative and/or quantitative analysis
• Terpene analysis
• Endocannabinoid (AEA, 2-AG, OEA et al.) quantification in biological matrices
• Amino acid analysis
• Bisphenols (A, S, F) quantification
• Analysis of high molecular weight species: proteins, DNA, RNA
• Residual solvent analysis (toluene, DCM, ethanol, etc.)
• Deuterium content calculation 

Custom designed analyses can be developed for targeted needs.

Submission procedure

Submission of samples for accurate mass analysis

Samples should be submitted as approximately 0.1 mg/mL solutions. The most suitable solvents are water, methanol, acetonitrile and dichloromethane. Total sample volume could vary between 0.1 and 1.5 ml. If you need to use other solvents (DMSO for example) or if you dispose of sample volumes smaller than the previously mentioned limit, ask for assistance.

Appropriate vials are available in Room B-4077 of the MIL campus.

Please fill-up the online form for each submitted sample.

Submission of samples for SFC

For analytical SFC analyses, the samples should be submitted as a solution around 1 mg/mL. The accepted solvants are methanol, isopropanol and hexanes. Samples containing water, DMF, DMSO or DCM are not suitable for analysis.

For preparative SFC, please submit samples neat.

Please fill-up the online form for each submitted sample.